FM fluorescent dyes (including FM 1-43, FM 2-10, FM 5-95, FM 4-64, etc.) are a class of lipophilic styryl fluorescent probes with low cellular toxicity. They are widely used in live cell membrane imaging, plant cell membrane labeling, neuronal tracing, and vesicular transport research (e.g., endocytosis/exocytosis processes)
Core Characteristics: High Water Solubility and Membrane-Dependent Fluorescence Activation
FM dyes exhibit high solubility in water and no fluorescent background. They emit strong fluorescence only upon binding to cell membranes or membrane-like structures. This characteristic makes them ideal tools for specific labeling of live cell membranes, particularly suitable for plant samples (e.g., root tips, leaf epidermis, etc.). Compared to other membrane dyes, the FM series offers advantages such as uniform staining, high signal intensity, and outstanding labeling specificity.
Neuroscience Research Applications: Synaptic Vesicle Dynamics Tracing
FM dyes can be internalized into recyclable synaptic vesicles of neurons, enabling specific labeling of neuronal terminals. This is used to track neurotransmitter release, visualize synaptic activity, and study dynamic neural circuits, providing a key tool for neurophysiology.
Typical Application Case: FM 1-43 Plant Cell Membrane Imaging
Taking FM 1-43 as an example, this dye enables high-resolution imaging of cell membranes in various plant cells (e.g., onion, tobacco, rice, Arabidopsis), clearly revealing membrane morphology in root tip cells, leaf epidermal cells, etc. It is the preferred fluorescent probe for plant cell biology and membrane dynamics research.
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Qian Zhaosheng, Ph.D. Professor | "Shuanglong Scholar" Distinguished Professor | Doctoral Supervisor |
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Education & Career
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Related Products
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FM 1-43 Dye, 95% （CAS 149838-22-2）
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- FM 4-64 Dye, 90% （CAS 162112-35-8）
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