The Pechmann condensation is a reaction in which phenols and β-keto esters react under acid catalysis to synthesize coumarin derivatives. It was first discovered by German chemist Hans Freiherr von Pechmann and is named after him. Coumarins are important intermediates in pharmaceuticals, agrochemicals, and functional materials. This reaction offers a...

Dess–Martin Oxidation refers to the oxidation of alcohols to the corresponding carbonyl compounds using Dess–Martin periodinane (DMP). The reaction is named after American chemists Daniel Benjamin Dess and James Cullen Martin. Dess–Martin periodinane (DMP), full name: 1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1H)-one, was developed in 1983 by the aforementioned chemists. The Dess–Martin oxidation can proceed...

Popular since the early 1900s, the 1,4-addition of Michael donors to activated π-systems (called Michael acceptors) to form new C-C bonds is known as the Michael addition or reaction. With the help of a base, the donor is converted to an enolate ion, which attacks the Michael acceptor. When a...

The BOC (tert-butoxycarbonyl) group is used to protect amines in synthetic reactions, is probably the most common amine protecting group in non-peptide chemistry. Di-tert-butyl dicarbonate, BOC2O (also known as di-tert-butyl pyrocarbonate or BOC anhydride), triethylamine (TEA), and tetrahydrofuran (THF) are commonly used to add the BOC group. The amine attacks a carbonyl...