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Sku 07-0956-50MG
STREM
| Technical Notes: 1.Conjugate Addition: Primary amine -thiourea derivative is an active and highly enantioselective catalyst for the conjugate addition of ketones to nitroalkenes. 2.Michael Addition: The asymmetric Michael addition of dioxindoles to ß-substituted nitroalkenes is reported. The bifunctional primary amine-thiourea, by means of a non-covalent-based mode of catalysis, secures direct access to 3-substituted 3-hydroxyoxindole derivatives with high stereocontrol. References: 1. J. Am. Chem. Soc., 2006, 128, 7170-7171. 2. Chem. Commun., 2012, 48, 3336-3338. |
