Product Name
α-D-Glucose-1,6-biphosphate tetra(cyclohexylammonium) salt hydrate, 95%
Molecular Formula
C6H14O12P2·4C6H13N·xH2O
Molecular Weight
736.81(anhydrous)
Certificate of Analysis (COA)
IUPAC Name
tetrakis(cyclohexanamine);(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(phosphonooxymethyl)oxan-2-yl dihydrogen phosphate;hydrate
InChI Key
DMUBREKUECBHKK-KMWDTYPGSA-N
SMILES
C1CCC(CC1)N.C1CCC(CC1)N.C1CCC(CC1)N.C1CCC(CC1)N.C(C@@H1C@H(C@@H(C@H(C@H(O1)OP(=O)(O)O)O)O)O)OP(=O)(O)O.O
Product Introduction
α-D-Glucose 1,6-Bisphosphate Tetra(cyclohexylammonium) Salt Hydrate (CAS No. 71662-13-0) is a high-purity glycolytic intermediate analogue widely used in biochemistry, enzymology, glycobiology, metabolic pathway research, and clinical diagnostic reagent development. As a stable salt form of α-D-glucose 1,6-bisphosphate (Glc-1,6-BP), it serves as a valuable research reagent for investigating carbohydrate metabolism and phosphotransfer reactions.
Glucose 1,6-bisphosphate is a naturally occurring metabolite that functions as an activator or cofactor for several enzymes involved in glycolysis and glycogen metabolism, including phosphoglucomutase (PGM). The tetra(cyclohexylammonium) salt provides improved stability and handling for laboratory applications.
Chemical Properties
Chemical Information
| Property |
Value |
| Chemical Name |
α-D-Glucose 1,6-Bisphosphate Tetra(cyclohexylammonium) Salt Hydrate |
| Synonyms |
α-D-Glucose 1,6-Diphosphate Tetra(cyclohexylammonium) Salt Hydrate; Glc-1,6-PP·4CHA |
| CAS Number |
71662-13-0 |
| Molecular Formula |
C₃₀H₆₈N₄O₁₃P₂·xH₂O |
| Molecular Weight |
Approximately 754.8 g/mol (hydrate form) |
| Appearance |
White to off-white powder |
| Purity |
Typically ≥95% |
Chemical Characteristics
- Stable glucose bisphosphate derivative
- High aqueous solubility after dissolution
- Excellent biochemical compatibility
- Suitable for enzyme activity studies
- High purity for analytical applications
- Ideal for carbohydrate metabolism research
Key Research Applications
1.Glycolysis Research
This compound serves as a valuable analogue for studying intermediates in glycolysis and glucose metabolism.
Typical applications include:
- Glycolytic pathway studies
- Glucose metabolism research
- Energy metabolism
- Carbohydrate biochemistry
- Metabolic regulation
2.Phosphoglucomutase (PGM) Studies
Glucose 1,6-bisphosphate is widely recognized as an important activator/cofactor for phosphoglucomutase and is frequently used in mechanistic and kinetic studies.
Typical applications include:
- PGM activation assays
- Enzyme kinetics
- Catalytic mechanism studies
- Cofactor evaluation
- Enzyme regulation research
3.Enzymology & Biochemistry
The compound is extensively used to investigate carbohydrate-metabolizing enzymes and phosphotransfer reactions.
Typical applications include:
- Enzyme activity assays
- Metabolic enzyme characterization
- Reaction pathway analysis
- Cofactor screening
- Biochemical assay development
4.Glycobiology Research
As a phosphorylated carbohydrate derivative, this reagent supports studies involving glycan metabolism and carbohydrate biochemistry.
Typical applications include:
- Glycan metabolism
- Carbohydrate chemistry
- Glycobiology
- Sugar phosphate research
- Metabolic pathway analysis
5.Analytical & Diagnostic Research
The compound is useful as a reference reagent and analytical standard in biochemical assay development.
Typical applications include:
- Reference standards
- Diagnostic reagent development
- Analytical method validation
- Laboratory quality control
- Research assay optimization
Recommended Experimental Conditions
| Parameter |
Recommended Conditions |
| Storage |
-20°C |
| Moisture Protection |
Recommended |
| Solvent |
Water or appropriate biological buffer |
| Light Protection |
Recommended |
| Application |
Biochemical and enzymatic assays |
Advantages
- High-purity glucose bisphosphate analogue
- Excellent enzyme compatibility
- Reliable cofactor for phosphoglucomutase studies
- Suitable for glycolysis and glycogen metabolism research
- High reproducibility in biochemical assays
- Ideal for metabolic pathway investigation
- Research-grade quality
Storage & Handling
Recommended storage temperature: -20 “C
Store in a cool place. Keep container tightly closed in a dry and well ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Research Areas
- Glycolysis
- Carbohydrate metabolism
- Enzymology
- Glycobiology
- Clinical biochemistry
- Metabolic engineering
- Analytical chemistry
- Biochemical assay development
Frequently Asked Questions (FAQ)
What is α-D-Glucose 1,6-Bisphosphate Tetra(cyclohexylammonium) Salt Hydrate used for?
It is primarily used in glycolysis research, phosphoglucomutase studies, enzymology, glycobiology, and biochemical assay development.
Why is glucose 1,6-bisphosphate important in metabolism?
Glucose 1,6-bisphosphate functions as an important regulator and activator of enzymes involved in carbohydrate metabolism, particularly phosphoglucomutase, which catalyzes the interconversion of glucose-1-phosphate and glucose-6-phosphate.
Can this compound be used for enzyme kinetics?
Yes. It is widely employed in enzyme kinetics, catalytic mechanism studies, cofactor evaluation, and biochemical assay development.
Is this product suitable for glycobiology research?
Yes. It is frequently used to investigate glycan metabolism, carbohydrate biochemistry, and phosphorylated sugar intermediates.
Why is the tetra(cyclohexylammonium) salt form used?
The tetra(cyclohexylammonium) salt improves handling, stability, and isolation of glucose 1,6-bisphosphate for laboratory research applications.
How should this product be stored?
For optimal stability, store the product at -20°C in a tightly sealed container and protect it from moisture.
Is this product intended for research use only?
Yes. This product is supplied for laboratory research, biochemical studies, analytical testing, and industrial R&D applications only.
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