Organic azides are compounds containing an azido group. Since the first synthesis of an organic azide (phenyl azide) by scientist P. J. Griess in 1864, these compounds have found widespread application in materials science and chemical biology due to their unique reactivity and biological activity. The azido group serves as a versatile chemical handle, enabling a broad range of transformations, including aza-Wittig reactions, Schmidt rearrangements, C-H amination, Staudinger ligation, and click chemistry.

In 2024, the research team led by Prof. Xue Xiaosong at the Shanghai Institute of Organic Chemistry (SIOC) proposed a predictive model for the activity and selectivity of diazotransfer reactions. Utilizing physicochemical data from their self-developed fluorinated reagent database, FluoBase (https://fluobase.siochemdb.com), the team successfully developed PSIA-II—a diazotransfer reagent that exhibits both ultra-high activity and remarkable stability.

Key Product Advantages

1. High Activity: Enables rapid diazotransfer reactions (5-20 minutes) for primary amines under mild conditions.

2. Excellent Stability: Insensitive to water and oxygen. Can be stored at -20°C for at least two months without significant decomposition.

3. Broad Application Potential: Holds significant promise for applications in organic synthesis, drug discovery (see Figure 1), materials chemistry, and chemical biology.