{"product_id":"j5326505","title":"Di-tert-butyl dicarbonate, 1.0M solution in THF | 24424-99-5","description":"\u003cstyle\u003e\n  \/* isQuote *\/\n  div.swatch.clearfix {\n    display:  unset ;\n  }\n\n  \/* Hide sku *\/\n  .product-sku, \n  #leadtimetext {\n    display: none !important;\n  }\n\n  \/* Square brackets *\/\n  span.l_bracket:before {\n    content: \"[\";\n  }\n  span.r_bracket:after {\n    content: \"]\";\n  }\n\n  \/* Hazard Symbols *\/\n  .ghs-symbols-row {\n    display: flex;\n    flex-wrap: wrap;\n    gap: 10px;\n  }\n\n  .hazard-symbol-container {\n    width: 50px;\n  }\n\n  .hazard-symbol {\n    object-fit: contain;\n    aspect-ratio: 1 \/ 1;\n    width: 100%;\n  }\n\n  \/* Section *\/\n  .section-header {\n    font-size: 1.5rem;\n    font-weight: bold;\n    color: #239ab7;\n    background-color: #f2f2f2;\n    padding: 10px;\n    border-radius: 4px;\n  }\n\n  .section-row {\n    display: grid;\n    grid-template-columns: repeat(8, 1fr);\n    padding: 6px 10px;\n   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1.3rem !important;\n    line-height: 1.5rem !important;\n  }\n\n  \/* SDS Search *\/\n  .section-row .coa-search-container {\n    display: flex;\n    align-items: center;\n    margin-top: 6px;\n  }\n\n  .section-row .coa-search-container input {\n    border: 1px solid #e0e0e0;\n    height: 2.5rem;\n    border-top-left-radius: 0.5rem !important;\n    border-bottom-left-radius: 0.5rem !important;\n    padding: 3px 5px;\n  }\n\n  .section-row .coa-search-container button {\n    height: 2.5rem;\n    line-height: 2.5rem;\n    border-radius: 0 0.5rem 0.5rem 0;\n  }\n\n  .section-row .coa-search-container button .coa-search-button-content {\n    display: flex;\n    align-items: center;\n    justify-content: center;\n    gap: 3px;\n  }\n\n  .section-row .coa-search-container button .coa-search-button-content .search-spin {\n    display: none;\n    width: 2rem;\n  }\n\n  .section-row .coa-search-container .coa-not-found {\n    display: none;\n    margin: 0 0 0 2rem;\n    color: #ad2031;\n    font-size: 1.3rem;\n  }\n\n  \/* Table *\/\n  .html-area table {\n    width: 100%;\n    border-collapse: collapse;\n    margin: 15px 0;\n  }\n\n  .html-area table th,\n  .html-area table td {\n    border: 1px solid #e0e0e0;\n    padding: 5px 8px;\n  }\n\n  @media (max-width: 600px) {\n    .section-row {\n      grid-template-columns: repeat(1, 1fr);\n    }\n\n    .section-row .row-key {\n      grid-column: 1 \/ 2;\n    }\n\n    .section-row .row-value {\n      grid-column: 1 \/ 2;\n    }\n\n    .hazard-grid {\n      grid-template-columns: repeat(2, 1fr);\n      gap: 0 20px;\n    }\n  }\n  \n\u003c\/style\u003e\n\n\u003cdiv class=\"section\"\u003e\n  \n\n    \u003c!-- Order Info --\u003e\n    \u003ch2 class=\"section-header\"\u003eProduct Information\u003c\/h2\u003e\n    \u003cdiv class=\"section-content\"\u003e\n        \n        \u003cdiv class=\"section-row\"\u003e\n            \u003cdiv class=\"row-key\"\u003eProduct Name\u003c\/div\u003e\n            \u003cdiv class=\"row-value\"\u003eDi-tert-butyl dicarbonate, 1.0M solution in THF\u003c\/div\u003e\n        \u003c\/div\u003e\n        \n        \n        \n        \u003cdiv class=\"section-row\"\u003e\n            \u003cdiv class=\"row-key\"\u003eBrand Name\u003c\/div\u003e\n            \u003cdiv class=\"row-value\"\u003eChem Impex\u003c\/div\u003e\n        \u003c\/div\u003e\n        \n\n        \n        \u003cdiv class=\"section-row\"\u003e\n            \u003cdiv class=\"row-key\"\u003eProduct Number\u003c\/div\u003e\n            \u003cdiv class=\"row-value\"\u003e26505\u003c\/div\u003e\n        \u003c\/div\u003e\n        \n\n        \n        \u003cdiv class=\"section-row\"\u003e\n            \u003cdiv class=\"row-key\"\u003eCAS\u003c\/div\u003e\n            \u003cdiv class=\"row-value\"\u003e24424-99-5\u003c\/div\u003e\n        \u003c\/div\u003e\n        \n\n        \n\n        \n\n        \n\n        \u003cdiv class=\"section-row\"\u003e\n            \u003cdiv class=\"row-key\"\u003eCertificate of Analysis (COA)​\u003c\/div\u003e\n            \u003cdiv class=\"row-value\"\u003e\n                \u003cdiv class=\"coa-search-container\"\u003e\n                    \u003cinput id=\"coa-link-input\" type=\"text\" placeholder=\"Enter Lot No.\"\u003e\n                    \u003cbutton id=\"coa-search-button\"\u003e\n                        \u003cdiv class=\"coa-search-button-content\"\u003e\n                            \u003csvg class=\"search-spin\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 200 200\"\u003e\u003cradialgradient id=\"a7\" cx=\".66\" fx=\".66\" cy=\".3125\" fy=\".3125\" gradienttransform=\"scale(1.5)\"\u003e\u003cstop offset=\"0\" stop-color=\"#FFFFFF\"\u003e\u003c\/stop\u003e\u003cstop offset=\".3\" stop-color=\"#FFFFFF\" stop-opacity=\".9\"\u003e\u003c\/stop\u003e\u003cstop offset=\".6\" stop-color=\"#FFFFFF\" stop-opacity=\".6\"\u003e\u003c\/stop\u003e\u003cstop offset=\".8\" stop-color=\"#FFFFFF\" stop-opacity=\".3\"\u003e\u003c\/stop\u003e\u003cstop offset=\"1\" stop-color=\"#FFFFFF\" stop-opacity=\"0\"\u003e\u003c\/stop\u003e\u003c\/radialgradient\u003e\u003ccircle transform-origin=\"center\" fill=\"none\" stroke=\"url(#a7)\" stroke-width=\"15\" stroke-linecap=\"round\" stroke-dasharray=\"200 1000\" stroke-dashoffset=\"0\" cx=\"100\" cy=\"100\" r=\"70\"\u003e\u003canimatetransform type=\"rotate\" attributename=\"transform\" calcmode=\"spline\" dur=\"2\" values=\"360;0\" keytimes=\"0;1\" keysplines=\"0 0 1 1\" repeatcount=\"indefinite\"\u003e\u003c\/animatetransform\u003e\u003c\/circle\u003e\u003ccircle transform-origin=\"center\" fill=\"none\" opacity=\".2\" stroke=\"#FFFFFF\" stroke-width=\"15\" stroke-linecap=\"round\" cx=\"100\" cy=\"100\" r=\"70\"\u003e\u003c\/circle\u003e\u003c\/svg\u003e\n                            \u003cspan\u003eSearch\u003c\/span\u003e\n                        \u003c\/div\u003e\n                    \u003c\/button\u003e\n                    \u003cspan class=\"coa-not-found\"\u003eCOA not found\u003c\/span\u003e\n                \u003c\/div\u003e\n            \u003c\/div\u003e\n        \u003c\/div\u003e\n\n    \u003c\/div\u003e\n\n    \u003c!-- General Info --\u003e\n    \n        \u003ch2 class=\"section-header\"\u003eGeneral Information\u003c\/h2\u003e\n        \u003cdiv class=\"section-content\"\u003e\n            \n\n            \n            \u003cdiv class=\"section-row\"\u003e\n                \u003cdiv class=\"row-key\"\u003ePubChem CID\u003c\/div\u003e\n                \u003cdiv class=\"row-value\"\u003e90495\u003c\/div\u003e\n            \u003c\/div\u003e\n            \n\n            \n                \u003cdiv class=\"section-row\"\u003e\n                    \u003cdiv class=\"row-key\"\u003eIUPAC Name\u003c\/div\u003e\n                    \u003cdiv class=\"row-value\"\u003etert-butyl (2-methylpropan-2-yl)oxycarbonyl carbonate\u003c\/div\u003e\n                \u003c\/div\u003e\n            \n\n            \n                \u003cdiv class=\"section-row\"\u003e\n                    \u003cdiv class=\"row-key\"\u003eInChI Key\u003c\/div\u003e\n                    \u003cdiv class=\"row-value\"\u003eDYHSDKLCOJIUFX-UHFFFAOYSA-N\u003c\/div\u003e\n                \u003c\/div\u003e\n            \n\n            \n                \u003cdiv class=\"section-row\"\u003e\n                    \u003cdiv class=\"row-key\"\u003eSMILES\u003c\/div\u003e\n                    \u003cdiv class=\"row-value\"\u003eCC(C)(C)OC(=O)OC(=O)OC(C)(C)C\u003c\/div\u003e\n                \u003c\/div\u003e\n            \n        \u003c\/div\u003e\n    \n\n    \u003c!-- Properties --\u003e\n    \n\n    \u003c!-- Safety Info --\u003e\n    \n\n    \u003c!-- Application  --\u003e\n    \n    \u003ch2 class=\"section-header\"\u003eApplication\u003c\/h2\u003e\n    \u003cdiv class=\"html-area\"\u003e\n        \u003ch2\u003eProduct Introduction\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eDi-tert-butyl dicarbonate (Boc₂O)\u003c\/strong\u003e is a widely used \u003cstrong\u003eamine-protecting reagent\u003c\/strong\u003e in organic synthesis, peptide chemistry, and pharmaceutical research. It is primarily employed for introducing the \u003cstrong\u003etert-butoxycarbonyl (Boc) protecting group\u003c\/strong\u003e onto amines, amino acids, and related compounds.\u003c\/p\u003e\n\u003cp\u003eBoc protection is a fundamental strategy in multi-step synthesis, allowing selective manipulation of reactive functional groups while maintaining synthetic control. Due to its high efficiency and broad substrate compatibility, Boc₂O is extensively used in \u003cstrong\u003epeptide synthesis, medicinal chemistry, and fine chemical production\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp\u003eIts mild reaction conditions and reliable performance make it an essential reagent for \u003cstrong\u003eprotecting group chemistry and synthetic route development\u003c\/strong\u003e.\u003c\/p\u003e\n\u003ch2\u003eChemical Properties and Reaction Mechanism\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eDi-tert-butyl dicarbonate\u003c\/strong\u003e functions as a \u003cstrong\u003ecarbonylating and amine-protecting reagent\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp\u003eIn synthetic reactions:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eBoc₂O reacts with primary and secondary amines\u003c\/li\u003e\n\u003cli\u003eIntroduces the tert-butoxycarbonyl (Boc) protecting group\u003c\/li\u003e\n\u003cli\u003eProduces Boc-protected derivatives under mild conditions\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eTypical reaction features:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eCompatible with amino acids, amines, and peptides\u003c\/li\u003e\n\u003cli\u003eFrequently used in the presence of organic bases\u003c\/li\u003e\n\u003cli\u003eDeprotection can be achieved under acidic conditions\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThis chemistry enables efficient functional group protection during multi-step organic synthesis.\u003c\/p\u003e\n\u003ch2\u003eKey Research Applications\u003c\/h2\u003e\n\u003ch3\u003e1.Organic Synthesis\u003c\/h3\u003e\n\u003cp\u003eBoc₂O is widely used in \u003cstrong\u003esynthetic organic chemistry\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp\u003eTypical applications include:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAmine protection reactions\u003c\/li\u003e\n\u003cli\u003eMulti-step synthesis workflows\u003c\/li\u003e\n\u003cli\u003eFunctional group transformation strategies\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e2.Peptide and Amino Acid Chemistry\u003c\/h3\u003e\n\u003cp\u003eThe reagent plays an important role in \u003cstrong\u003epeptide synthesis\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp\u003eApplications include:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAmino acid protection\u003c\/li\u003e\n\u003cli\u003ePeptide intermediate preparation\u003c\/li\u003e\n\u003cli\u003eSolid-phase and solution-phase synthesis\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e3.Pharmaceutical and Medicinal Chemistry\u003c\/h3\u003e\n\u003cp\u003eBoc₂O is extensively applied in \u003cstrong\u003edrug discovery and pharmaceutical development\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp\u003eApplications include:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAPI intermediate synthesis\u003c\/li\u003e\n\u003cli\u003eLead compound preparation\u003c\/li\u003e\n\u003cli\u003eMedicinal chemistry optimization\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e4.Chemical Process Development\u003c\/h3\u003e\n\u003cp\u003eUseful in \u003cstrong\u003elaboratory and industrial synthesis\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp\u003eApplications include:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eSynthetic route design\u003c\/li\u003e\n\u003cli\u003eProcess optimization\u003c\/li\u003e\n\u003cli\u003eFine chemical manufacturing\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eRecommended Experimental Conditions\u003c\/h2\u003e\n\u003cdiv\u003e\u003cdiv\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eParameter\u003c\/th\u003e\n\u003cth\u003eRecommended Conditions\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eReaction Type\u003c\/td\u003e\n\u003ctd\u003eBoc protection of amines\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSolvent Systems\u003c\/td\u003e\n\u003ctd\u003eDCM, THF, acetonitrile, dioxane, or mixed solvents\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBase Conditions\u003c\/td\u003e\n\u003ctd\u003eTriethylamine, sodium bicarbonate, or related bases\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTemperature\u003c\/td\u003e\n\u003ctd\u003eRoom temperature or controlled cooling\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eReaction Format\u003c\/td\u003e\n\u003ctd\u003eSolution-phase organic synthesis\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003c\/div\u003e\u003c\/div\u003e\n\u003cp\u003e\u003ci\u003eReaction conditions should be optimized according to substrate and synthetic design.\u003c\/i\u003e\u003c\/p\u003e\n\u003ch2\u003eAdvantages in Synthetic Applications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eEfficient amine protection reagent\u003c\/li\u003e\n\u003cli\u003eMild and broadly compatible reaction conditions\u003c\/li\u003e\n\u003cli\u003eWidely used in peptide and pharmaceutical synthesis\u003c\/li\u003e\n\u003cli\u003eSupports selective multi-step synthetic strategies\u003cul\u003e\u003cli\u003eReliable and scalable chemistry\u003c\/li\u003e\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eResearch Areas\u003c\/h2\u003e\n\u003cp\u003eResearchers working in the following fields may benefit from this compound:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eOrganic synthesis and protecting group chemistry\u003c\/li\u003e\n\u003cli\u003ePeptide and amino acid research\u003c\/li\u003e\n\u003cli\u003eMedicinal and pharmaceutical chemistry\u003c\/li\u003e\n\u003cli\u003eSynthetic methodology development\u003c\/li\u003e\n\u003cli\u003eFine chemical and process chemistry research\u003c\/li\u003e\n\u003c\/ul\u003e\n    \u003c\/div\u003e\n    \n\n    \u003c!-- Faq --\u003e\n    \n    \u003ch2 class=\"section-header\"\u003eFAQ\u003c\/h2\u003e\n    \u003cdiv class=\"html-area\"\u003e\n        \u003ch2\u003eFrequently Asked Questions (FAQ)\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eWhat is Di-tert-butyl dicarbonate used for?\u003c\/strong\u003e\u003cbr\u003eIt is widely used as a \u003cstrong\u003eBoc-protecting reagent for amines, amino acids, and peptides\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhat functional group does Boc₂O protect?\u003c\/strong\u003e\u003cbr\u003eBoc₂O primarily reacts with \u003cstrong\u003eamine groups\u003c\/strong\u003e, introducing the \u003cstrong\u003etert-butoxycarbonyl (Boc) protecting group\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhy is Boc protection important in synthesis?\u003c\/strong\u003e\u003cbr\u003eBecause it enables \u003cstrong\u003eselective control of amine reactivity\u003c\/strong\u003e during multi-step organic and peptide synthesis.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHow are Boc-protected compounds deprotected?\u003c\/strong\u003e\u003cbr\u003eBoc groups are typically removed under \u003cstrong\u003eacidic conditions\u003c\/strong\u003e, commonly using reagents such as TFA or HCl-based systems.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCan Boc₂O be used in peptide synthesis?\u003c\/strong\u003e\u003cbr\u003eYes, it is extensively used in \u003cstrong\u003eamino acid protection and peptide intermediate preparation\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhat solvents are commonly used with Boc₂O?\u003c\/strong\u003e\u003cbr\u003eCommon solvent systems include \u003cstrong\u003eDCM, THF, acetonitrile, and dioxane\u003c\/strong\u003e, depending on substrate compatibility.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDoes Boc₂O require a base during reactions?\u003c\/strong\u003e\u003cbr\u003eIn many procedures, \u003cstrong\u003eorganic or inorganic bases\u003c\/strong\u003e are used to facilitate efficient protection reactions.\u003c\/p\u003e\n    \u003c\/div\u003e\n    \n\n    \u003c!-- References --\u003e\n    \n    \u003ch2 class=\"section-header\"\u003eReferences\u003c\/h2\u003e\n    \u003cdiv class=\"section-content\"\u003e\n        \n            \u003cdiv class=\"reference-item\"\u003e\n                \n                    \n                    \u003ca href=\"https:\/\/doi.org\/10.1134\/s1070363225606003\" target=\"_blank\" rel=\"noopener noreferrer\"\u003e\n                        \u003ch3\u003eSynthesis and Properties of 4-Amino-5-oxoproline Derivatives (A Review)\u003c\/h3\u003e\n                    \u003c\/a\u003e\n                    \n                \n\n                \n                \u003cdiv class=\"publication-item\"\u003ePublication Name: Russian Journal of General Chemistry\u003c\/div\u003e\n                \n\n                \n                \u003cdiv class=\"publication-item\"\u003ePublication Date: 2026-02-24\u003c\/div\u003e\n                \n\n                \n                \u003cdiv class=\"publication-item\"\u003eDOI: 10.1134\/s1070363225606003\u003c\/div\u003e\n                \n            \u003c\/div\u003e\n        \n            \u003cdiv class=\"reference-item\"\u003e\n                \n                    \n                    \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC13061622\" target=\"_blank\" rel=\"noopener noreferrer\"\u003e\n                        \u003ch3\u003eElectron hopping in conjugated molecular wires with application to solar cells\u003c\/h3\u003e\n                    \u003c\/a\u003e\n                    \n                \n\n                \n                \u003cdiv class=\"publication-item\"\u003ePublication Name: Nature Chemistry\u003c\/div\u003e\n                \n\n                \n                \u003cdiv class=\"publication-item\"\u003ePublication Date: 2026-02-09\u003c\/div\u003e\n                \n\n                \n                \u003cdiv class=\"publication-item\"\u003eDOI: 10.1038\/s41557-025-02034-0\u003c\/div\u003e\n                \n            \u003c\/div\u003e\n        \n            \u003cdiv class=\"reference-item\"\u003e\n                \n                    \n                    \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC12934088\" target=\"_blank\" rel=\"noopener noreferrer\"\u003e\n                        \u003ch3\u003eGlutathione responsive iNOS inhibiting polymeric prodrug for targeted Inhibition of angiogenesis\u003c\/h3\u003e\n                    \u003c\/a\u003e\n                    \n                \n\n                \n                \u003cdiv class=\"publication-item\"\u003ePublication Name: Journal of Nanobiotechnology\u003c\/div\u003e\n                \n\n                \n                \u003cdiv class=\"publication-item\"\u003ePublication Date: 2026-01-30\u003c\/div\u003e\n                \n\n                \n                \u003cdiv class=\"publication-item\"\u003eDOI: 10.1186\/s12951-026-04022-z\u003c\/div\u003e\n                \n            \u003c\/div\u003e\n        \n            \u003cdiv class=\"reference-item\"\u003e\n                \n                    \n                    \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41593291\" target=\"_blank\" rel=\"noopener noreferrer\"\u003e\n                        \u003ch3\u003eBiosensing device based on optical waveguide spectrometry with fluorescent solvatochromic beads for label-free tracking of avidin–biotin interaction\u003c\/h3\u003e\n                    \u003c\/a\u003e\n                    \n                \n\n                \n                \u003cdiv class=\"publication-item\"\u003ePublication Name: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry\u003c\/div\u003e\n                \n\n                \n                \u003cdiv class=\"publication-item\"\u003ePublication Date: 2026-01-28\u003c\/div\u003e\n                \n\n                \n                \u003cdiv class=\"publication-item\"\u003eDOI: 10.1007\/s44211-025-00865-y\u003c\/div\u003e\n                \n            \u003c\/div\u003e\n        \n            \u003cdiv class=\"reference-item\"\u003e\n                \n                    \n                    \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41575477\" target=\"_blank\" rel=\"noopener noreferrer\"\u003e\n                        \u003ch3\u003ePalladium-catalyzed Suzuki–Miyaura and Buchwald–Hartwig cross-coupling reactions towards the synthesis of pharmacologically potent pyrimidine-based molecules\u003c\/h3\u003e\n                    \u003c\/a\u003e\n                    \n                \n\n                \n                \u003cdiv class=\"publication-item\"\u003ePublication Name: Molecular Diversity\u003c\/div\u003e\n                \n\n                \n                \u003cdiv class=\"publication-item\"\u003ePublication Date: 2026-01-23\u003c\/div\u003e\n                \n\n                \n                \u003cdiv class=\"publication-item\"\u003eDOI: 10.1007\/s11030-025-11459-1\u003c\/div\u003e\n                \n            \u003c\/div\u003e\n        \n    \u003c\/div\u003e\n    \n\n\n    \u003cscript\u003e\n        const coaSearchButton = document.getElementById('coa-search-button');\n        coaSearchButton.addEventListener('click', async function() {\n            const coaLinkInput = document.getElementById('coa-link-input');\n            const spinElement = document.querySelector('.search-spin');\n            const notFoundElement = document.querySelector('.coa-not-found');\n\n            const lot = coaLinkInput.value.trim().toUpperCase();\n            if (lot.length \u003e 0) {\n                spinElement.style.display = 'block';\n                notFoundElement.style.display = 'none';\n\n                const url = 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