{"product_id":"corey-lactone-diol-98-cas-32233-40-2","title":"(-)-Corey Lactone Diol, 98% | CAS 32233-40-2","description":"\u003ch2\u003eProduct Information\u003c\/h2\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eProduct Name\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e(-)-Corey Lactone Diol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eIUPAC Name\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e(3aR,4S,5R,6aS)-5-Hydroxy-4-(hydroxymethyl)-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-one\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eCAS Number\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e32233-40-2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMolecular Formula\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eC₈H₁₂O₄\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e172.18 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMDL Number\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eMFCD00075234\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003ePubChem CID\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e2724453\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e≥98% (GC)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eAppearance\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eWhite to off-white crystalline powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMelting Point\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e115–119 °C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eBoiling Point\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e406.6 °C at 760 mmHg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSpecific Rotation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e[α]²⁰\/D = −39° (c = 1, MeOH)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSolubility\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eSoluble in DMSO (34 mg\/mL), methanol, and chloroform\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eInChI Key\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eVYTZWRCSPHQSFX-GBNDHIKLSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSMILES\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eOC[C@H]1[C@H](O)C[C@@H]2OC(=O)C[C@H]12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eRoom temperature, dry, and sealed. Recommended below 15 °C.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSynonyms\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e(-)-Corey Lactone; Corey Lactone Diol; L-Corey Lactone; (-)-Corey Diol; (3aR,4S,5R,6aS)-(-)-Hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cdiv\u003e\n\u003ch2 class=\"rich-text-paragraph\"\u003e\n\u003cspan class=\"text-only\"\u003e\u003c\/span\u003e\u003cbr\u003e\n\u003c\/h2\u003e\n\u003ch2 class=\"rich-text-paragraph\"\u003e\u003cspan class=\"text-only\"\u003eApplications\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch3 class=\"rich-text-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"text-only\"\u003eProstaglandin Drug Synthesis\u003c\/span\u003e\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cdiv class=\"rich-text-paragraph\"\u003e\u003cspan class=\"text-only\"\u003e(-)-Corey lactone diol is the most widely used starting material in the industrial synthesis of prostaglandin-based therapeutics, including:\u003c\/span\u003e\u003c\/div\u003e\n\u003cul class=\"richTextDocs-unOrderList richTextDocs-unOrderList-disc\"\u003e\n\u003cli class=\"richTextDocs-listItem\"\u003e\n\u003cdiv class=\"richTextDocs-listItem__text\"\u003e\n\u003cstrong\u003e\u003cspan class=\"text-only\"\u003eGlaucoma medications\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"text-only\"\u003e — latanoprost, travoprost, bimatoprost, and tafluprost (prostaglandin F₂α analogs that reduce intraocular pressure)\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli class=\"richTextDocs-listItem\"\u003e\n\u003cdiv class=\"richTextDocs-listItem__text\"\u003e\n\u003cstrong\u003e\u003cspan class=\"text-only\"\u003ePulmonary hypertension therapies\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"text-only\"\u003e — beraprost and iloprost (prostacyclin analogs with vasodilatory and antiplatelet properties)\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli class=\"richTextDocs-listItem\"\u003e\n\u003cdiv class=\"richTextDocs-listItem__text\"\u003e\n\u003cstrong\u003e\u003cspan class=\"text-only\"\u003eReproductive health agents\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"text-only\"\u003e — misoprostol and carboprost (prostaglandin E₁ and F₂α analogs used in obstetrics and gastroenterology)\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli class=\"richTextDocs-listItem\"\u003e\n\u003cdiv class=\"richTextDocs-listItem__text\"\u003e\n\u003cstrong\u003e\u003cspan class=\"text-only\"\u003eAntiviral agents\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"text-only\"\u003e — entecavir (a nucleoside analog for hepatitis B, whose formal synthesis uses the Corey lactone skeleton)\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3 class=\"rich-text-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"text-only\"\u003eAsymmetric Synthesis and Medicinal Chemistry\u003c\/span\u003e\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cdiv class=\"rich-text-paragraph\"\u003e\u003cspan class=\"text-only\"\u003eBeyond the prostaglandin family, Corey lactone diol serves as a versatile chiral synthon for constructing enantiomerically pure cyclopentanoid natural products and their analogs. Its well-defined stereochemistry, functional group compatibility, and commercial availability in enantiopure form make it a preferred starting material in academic total synthesis and pharmaceutical process development.\u003c\/span\u003e\u003c\/div\u003e\n\u003ch3 class=\"rich-text-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"text-only\"\u003eStructure–Activity Relationship (SAR) Studies\u003c\/span\u003e\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cdiv class=\"rich-text-paragraph\"\u003e\n\u003cspan class=\"text-only\"\u003eResearchers employ Corey lactone diol to rapidly generate libraries of prostaglandin analogs with modified side chains, enabling systematic exploration of structure–activity relationships for anti-inflammatory, cardiovascular, and oncological targets.\u003c\/span\u003e\u003cspan class=\"text-only\"\u003e\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rich-text-paragraph\"\u003e\n\u003ch2\u003e\n\u003cspan class=\"text-only\"\u003eHandling and Safety\u003c\/span\u003e\u003cspan class=\"text-only\"\u003e \u003c\/span\u003e\n\u003c\/h2\u003e\n\u003cdiv\u003e\n\u003cspan class=\"text-only\"\u003eStore in a tightly sealed container at room temperature (recommended below 15 °C) in a dry environment. Avoid exposure to moisture and strong oxidizing agents. Refer to the Safety Data Sheet (SDS) for detailed handling precautions.\u003c\/span\u003e\u003cspan class=\"text-only\"\u003e \u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv\u003e\n\u003ca rel=\"noopener noreferrer\" class=\"link rich-text-anchor __anchor-intercept-flag__ text-content-link\" href=\"https:\/\/www.jk-sci.com\/pages\/request-safety-data-sheets-sds\" target=\"_blank\"\u003eRequest SDS\u003c\/a\u003e\u003cspan class=\"text-only\"\u003e | \u003c\/span\u003e\u003ca rel=\"noopener noreferrer\" class=\"link rich-text-anchor __anchor-intercept-flag__ text-content-link\" href=\"https:\/\/www.jk-sci.com\/pages\/request-certificates-of-analysis-coa\" target=\"_blank\"\u003eRequest COA\u003c\/a\u003e\n\u003c\/div\u003e\n\u003cdiv\u003e\n\u003ch2\u003e\n\u003cspan class=\"text-only\"\u003eQuality Assurance\u003c\/span\u003e\u003cspan class=\"text-only\"\u003e \u003c\/span\u003e\n\u003c\/h2\u003e\n\u003cdiv\u003e\u003cspan class=\"text-only\"\u003eJ\u0026amp;K Scientific is ISO 9001:2015 certified. Each batch of (-)-Corey lactone diol is tested for purity (GC), melting point, specific rotation, and spectral conformity (IR, ¹H NMR) before release. A Certificate of Analysis (COA) is available upon request.\u003c\/span\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003ch2 class=\"rich-text-paragraph\"\u003e\u003cspan class=\"text-only\"\u003eRelated Products\u003c\/span\u003e\u003c\/h2\u003e\n\u003cul class=\"richTextDocs-unOrderList richTextDocs-unOrderList-disc\"\u003e\n\u003cli class=\"richTextDocs-listItem\"\u003e\n\u003cdiv class=\"richTextDocs-listItem__text\"\u003e\u003cspan class=\"text-only\"\u003e(+)-Corey Lactone Diol (CAS 76704-05-7) — the enantiomer\u003c\/span\u003e\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli class=\"richTextDocs-listItem\"\u003e\n\u003cdiv class=\"richTextDocs-listItem__text\"\u003e\u003cspan class=\"text-only\"\u003e(±)-Corey Lactone Diol (CAS 54423-47-1) — racemic form\u003c\/span\u003e\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli class=\"richTextDocs-listItem\"\u003e\n\u003cdiv class=\"richTextDocs-listItem__text\"\u003e\u003cspan class=\"text-only\"\u003eCorey Lactone 4-Phenylbenzoate (CAS 31752-99-5) — protected derivative\u003c\/span\u003e\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli class=\"richTextDocs-listItem\"\u003e\n\u003cdiv class=\"richTextDocs-listItem__text\"\u003e\u003cspan class=\"text-only\"\u003eCorey Aldehyde (CAS 40203-05-2) — the oxidized counterpart\u003c\/span\u003e\u003c\/div\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\n\u003cspan class=\"text-only\"\u003eBulk and Custom Orders\u003c\/span\u003e\u003cspan class=\"text-only\"\u003e \u003c\/span\u003e\n\u003c\/h2\u003e\n\u003cdiv\u003e\u003cspan class=\"text-only\"\u003eNeed larger quantities or custom specifications? J\u0026amp;K Scientific offers scale-up from grams to kilograms with competitive pricing and reliable supply. \u003c\/span\u003e\u003c\/div\u003e\n\u003cdiv\u003e\u003ca href=\"https:\/\/www.jk-sci.com\/pages\/request-bulk-quote\" title=\"J\u0026amp;K request-bulk-quote\" rel=\"noopener\" target=\"_blank\"\u003e\u003cspan class=\"text-only\"\u003eContact us for a bulk quote.\u003c\/span\u003e\u003c\/a\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003ch2 class=\"rich-text-paragraph\"\u003e\u003cspan class=\"text-only\"\u003eSelected Literature\u003c\/span\u003e\u003c\/h2\u003e\n\u003cul class=\"richTextDocs-unOrderList richTextDocs-unOrderList-disc\"\u003e\n\u003cli class=\"richTextDocs-listItem\"\u003e\n\u003cdiv class=\"richTextDocs-listItem__text\"\u003e\n\u003cspan class=\"text-only\"\u003eCorey, E. J.; Weinshenker, N. M.; Schaaf, T. K.; Huber, W. \u003c\/span\u003e\u003cem\u003e\u003cspan class=\"text-only text-font-italic\"\u003eJ. Am. Chem. Soc.\u003c\/span\u003e\u003c\/em\u003e\u003cspan class=\"text-only\"\u003e \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"text-only\"\u003e1969\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"text-only\"\u003e, 91, 5675–5677. (Seminal Corey lactone synthesis)\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli class=\"richTextDocs-listItem\"\u003e\n\u003cdiv class=\"richTextDocs-listItem__text\"\u003e\n\u003cspan class=\"text-only\"\u003eUmekubo, N.; Suga, Y.; Hayashi, Y. \u003c\/span\u003e\u003cem\u003e\u003cspan class=\"text-only text-font-italic\"\u003eChem. Sci.\u003c\/span\u003e\u003c\/em\u003e\u003cspan class=\"text-only\"\u003e \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"text-only\"\u003e2020\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"text-only\"\u003e, 11, 1205–1209. (One-pot enantioselective Corey lactone synthesis)\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli class=\"richTextDocs-listItem\"\u003e\n\u003cdiv class=\"richTextDocs-listItem__text\"\u003e\n\u003cspan class=\"text-only\"\u003eAchmatowicz, B. et al. \u003c\/span\u003e\u003cem\u003e\u003cspan class=\"text-only text-font-italic\"\u003eTetrahedron Lett.\u003c\/span\u003e\u003c\/em\u003e\u003cspan class=\"text-only\"\u003e \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"text-only\"\u003e1985\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"text-only\"\u003e, 26(45), 5597–5600. (BF₃-mediated prostaglandin approach from Corey lactone)\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"J\u0026K Scientific","offers":[{"title":"Default Title","offer_id":48836698603710,"sku":null,"price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0506\/0005\/0878\/files\/Corey_Lactone_Diol_98.png?v=1788414935","url":"https:\/\/www.jk-sci.com\/products\/corey-lactone-diol-98-cas-32233-40-2","provider":"J\u0026K Scientific LLC","version":"1.0","type":"link"}