{"product_id":"a019146843","title":"CH-1055 NHS Ester, 95%","description":"\u003cstyle\u003e\n  \/* isQuote *\/\n  div.swatch.clearfix {\n    display: none !important;\n  }\n\n  \/* Hide sku *\/\n  .product-sku, \n  #leadtimetext {\n    display: none !important;\n  }\n\n  \/* Square brackets *\/\n  span.l_bracket:before {\n    content: \"[\";\n  }\n  span.r_bracket:after {\n    content: \"]\";\n  }\n\n  \/* Hazard Symbols *\/\n  .ghs-symbols-row {\n    display: flex;\n    flex-wrap: wrap;\n    gap: 10px;\n  }\n\n  .hazard-symbol-container {\n    width: 50px;\n  }\n\n  .hazard-symbol {\n    object-fit: contain;\n    aspect-ratio: 1 \/ 1;\n    width: 100%;\n  }\n\n  \/* Section *\/\n  .section-header {\n    font-size: 1.5rem;\n    font-weight: bold;\n    color: #239ab7;\n    background-color: #f2f2f2;\n    padding: 10px;\n    border-radius: 4px;\n  }\n\n  .section-row {\n    display: grid;\n    grid-template-columns: repeat(8, 1fr);\n    padding: 6px 10px;\n    border-bottom: 1px solid 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}\n\n  \/* Table *\/\n  .html-area table {\n    width: 100%;\n    border-collapse: collapse;\n    margin: 15px 0;\n  }\n\n  .html-area table th,\n  .html-area table td {\n    border: 1px solid #e0e0e0;\n    padding: 5px 8px;\n  }\n\n  @media (max-width: 600px) {\n    .section-row {\n      grid-template-columns: repeat(1, 1fr);\n    }\n\n    .section-row .row-key {\n      grid-column: 1 \/ 2;\n    }\n\n    .section-row .row-value {\n      grid-column: 1 \/ 2;\n    }\n\n    .hazard-grid {\n      grid-template-columns: repeat(2, 1fr);\n      gap: 0 20px;\n    }\n  }\n  \n\u003c\/style\u003e\n\n\u003cdiv class=\"section\"\u003e\n  \n\n    \u003c!-- Order Info --\u003e\n    \u003ch2 class=\"section-header\"\u003eProduct Information\u003c\/h2\u003e\n    \u003cdiv class=\"section-content\"\u003e\n        \n        \u003cdiv class=\"section-row\"\u003e\n            \u003cdiv class=\"row-key\"\u003eProduct Name\u003c\/div\u003e\n            \u003cdiv class=\"row-value\"\u003eCH-1055 NHS Ester, 95%\u003c\/div\u003e\n        \u003c\/div\u003e\n        \n        \n        \n        \u003cdiv class=\"section-row\"\u003e\n            \u003cdiv class=\"row-key\"\u003eBrand Name\u003c\/div\u003e\n            \u003cdiv class=\"row-value\"\u003eJ\u0026amp;K\u003c\/div\u003e\n        \u003c\/div\u003e\n        \n\n        \n        \u003cdiv class=\"section-row\"\u003e\n            \u003cdiv class=\"row-key\"\u003eProduct Number\u003c\/div\u003e\n            \u003cdiv class=\"row-value\"\u003e9146843\u003c\/div\u003e\n        \u003c\/div\u003e\n        \n\n        \n\n        \n\n        \n\n        \n\n        \u003cdiv class=\"section-row\"\u003e\n            \u003cdiv class=\"row-key\"\u003eCertificate of Analysis (COA)​\u003c\/div\u003e\n            \u003cdiv class=\"row-value\"\u003e\n                \u003cdiv class=\"coa-search-container\"\u003e\n                    \u003cinput id=\"coa-link-input\" type=\"text\" placeholder=\"Enter Lot No.\"\u003e\n                    \u003cbutton id=\"coa-search-button\"\u003e\n                        \u003cdiv class=\"coa-search-button-content\"\u003e\n                            \u003csvg class=\"search-spin\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 200 200\"\u003e\u003cradialgradient id=\"a7\" cx=\".66\" fx=\".66\" cy=\".3125\" fy=\".3125\" gradienttransform=\"scale(1.5)\"\u003e\u003cstop offset=\"0\" stop-color=\"#FFFFFF\"\u003e\u003c\/stop\u003e\u003cstop offset=\".3\" stop-color=\"#FFFFFF\" stop-opacity=\".9\"\u003e\u003c\/stop\u003e\u003cstop offset=\".6\" stop-color=\"#FFFFFF\" stop-opacity=\".6\"\u003e\u003c\/stop\u003e\u003cstop offset=\".8\" stop-color=\"#FFFFFF\" stop-opacity=\".3\"\u003e\u003c\/stop\u003e\u003cstop offset=\"1\" stop-color=\"#FFFFFF\" stop-opacity=\"0\"\u003e\u003c\/stop\u003e\u003c\/radialgradient\u003e\u003ccircle transform-origin=\"center\" fill=\"none\" stroke=\"url(#a7)\" stroke-width=\"15\" stroke-linecap=\"round\" stroke-dasharray=\"200 1000\" stroke-dashoffset=\"0\" cx=\"100\" cy=\"100\" r=\"70\"\u003e\u003canimatetransform type=\"rotate\" attributename=\"transform\" calcmode=\"spline\" dur=\"2\" values=\"360;0\" keytimes=\"0;1\" keysplines=\"0 0 1 1\" repeatcount=\"indefinite\"\u003e\u003c\/animatetransform\u003e\u003c\/circle\u003e\u003ccircle transform-origin=\"center\" fill=\"none\" opacity=\".2\" stroke=\"#FFFFFF\" stroke-width=\"15\" stroke-linecap=\"round\" cx=\"100\" cy=\"100\" r=\"70\"\u003e\u003c\/circle\u003e\u003c\/svg\u003e\n                            \u003cspan\u003eSearch\u003c\/span\u003e\n                        \u003c\/div\u003e\n                    \u003c\/button\u003e\n                    \u003cspan class=\"coa-not-found\"\u003eCOA not found\u003c\/span\u003e\n                \u003c\/div\u003e\n            \u003c\/div\u003e\n        \u003c\/div\u003e\n\n    \u003c\/div\u003e\n\n    \u003c!-- General Info --\u003e\n    \n\n    \u003c!-- Properties --\u003e\n    \n\n    \u003c!-- Safety Info --\u003e\n    \n\n    \u003c!-- Application  --\u003e\n    \n    \u003ch2 class=\"section-header\"\u003eApplication\u003c\/h2\u003e\n    \u003cdiv class=\"html-area\"\u003e\n        \u003ch2\u003e\u003cspan\u003eGeneral Description\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan\u003eIn 2016, Professor Hong Xuechuan from Wuhan University published an article in Nature Materials, reporting the first successful synthesis of a near-infrared window II (NIR-II) small-molecule dye—CH1055—that can label various biomolecules and be metabolized by organisms.\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eIts maximum emission wavelength ranges from 1000 nm to 1600 nm. CH1055 is non-toxic, absorbable, and possesses good biocompatibility and imaging sensitivity. It can serve as a NIR-II reporter molecule for in vitro detection and in vivo imaging, as well as for detecting cellular markers, tissue specimens, early disease diagnosis, disease staging, intraoperative navigation, and postoperative efficacy evaluation.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan\u003eProduct Advantages\u003c\/span\u003e\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cp\u003e\u003cspan\u003eProvides additional modifiable sites for conjugating bioactive substances, thereby improving water solubility and biocompatibility.\u003c\/span\u003e\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp\u003e\u003cspan\u003eAbsorbable by the body and excreted via the kidneys.\u003c\/span\u003e\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp\u003e\u003cspan\u003eCompared with traditional NIR-II fluorescent dyes such as single-walled carbon nanotubes (SWNTs) and quantum dots (inorganic materials), CH1055 offers better biocompatibility, in vivo metabolism, and in vivo safety.\u003c\/span\u003e\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp\u003e\u003cspan\u003eWith a maximum emission wavelength between 1000 nm and 1600 nm, CH1055 exhibits deeper tissue penetration (up to ~40 μm) than NIR-I (700–1000 nm) fluorescent dyes.\u003c\/span\u003e\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp\u003e\u003cspan\u003eHigher imaging signal-to-noise ratio and resolution.\u003c\/span\u003e\u003c\/p\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\u003cspan\u003eApplications\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan\u003eCH1055 can be used as a NIR-II reporter molecule for in vitro detection and in vivo imaging, as well as for detecting cellular markers, tissue specimens, early disease diagnosis, disease staging, intraoperative navigation, and postoperative efficacy evaluation. Specific examples include:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cp\u003e\u003cspan\u003eAn innovative probe, CH1055-GRRRDEVDK (CH1055-GK), was synthesized using CH1055 to specifically bind caspase-3, enabling imaging of skin avulsion injuries and defining necrotic areas [1].\u003c\/span\u003e\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp\u003e\u003cspan\u003eCH1055-F3 demonstrated high spatial and temporal resolution, strong tumor uptake, and remarkable NIR-II image-guided surgery specificity in DMBA-induced spontaneous breast tumor rats [2].\u003c\/span\u003e\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp\u003e\u003cspan\u003eTwo homologous fluorescent probes, CH1055-PEG-PT and CH1055-PEG-BODY, showed promising results for targeted imaging of osteosarcoma and its lung metastases, respectively. The study found that NIR-II imaging quality of CH1055-PEG-PT far exceeded that of CT [3].\u003c\/span\u003e\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp\u003e\u003cspan\u003eThe cartilage-targeting probe CH1055-WL enabled visual monitoring of articular cartilage (AC) degeneration in living subjects [4].\u003c\/span\u003e\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp\u003e\u003cspan\u003eThe small-molecule NIR-II fluorophore CH1055 conjugated with FSH (FSH-CH) was used for imaging of ovaries and testes in live mice [5].\u003c\/span\u003e\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp\u003e\u003cspan\u003eThe NIR-II probe CH1055-MCM2 was evaluated in mice bearing HepG2 xenografts, achieving favorable imaging properties such as good tumor uptake, high tumor contrast, and specificity. This strategy may identify new targets for liver cancer imaging and therapy [6].\u003c\/span\u003e\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp\u003e\u003cspan\u003eThe uPAR-targeting probe CH1055-4Glu-AE105 enabled imaging of orthotopic glioblastoma (GBM) through an intact skull [7].\u003c\/span\u003e\u003c\/p\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\u003cspan\u003eReferences\u003c\/span\u003e\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e1、Li, Yizhou; Hu, Xiang; Yi, Wanrong; Li, Daifeng; Guo, Yaqi; Qi, Baiwen; Yu, Aixi，Frontiers in Chemistry (Lausanne, Switzerland) (2019), 7, 696.\u003c\/li\u003e\n\u003cli\u003e2、Zhou, Hui; Li, Shanshan; Zeng, Xiaodong; Hong, Xuechuan; et al. Chinese Chemical Letters (2020), 31(6), 1382-1386.\u003c\/li\u003e\n\u003cli\u003e3、Zhou, Hui; Yi, Wanrong. Li, Anguo. Wang, Tian. et al. Advanced Healthcare Materials (2020), 9(1), 1901224.\u003c\/li\u003e\n\u003cli\u003e4、Yi, Wanrong. Zhou, Hui. Li, Anguo. et al. Biomaterials Science (2019), 7(3), 1043-1051.\u003c\/li\u003e\n\u003cli\u003e5、Feng, Yi. Zhu, Shoujun. Antaris, Alexander L.. Chen, Hao. et al. Chemical Science (2017), 8(5), 3703-3711\u003c\/li\u003e\n\u003cli\u003e6、Yang, Jing. Xie, Qi. Zhou, Hui. Chang, Lei. et al. Journal of Proteome Research (2018), 17(7), 2428-2439.\u003c\/li\u003e\n\u003cli\u003e7、Kurbegovic, Sorel; Juhl, Karina; Chen, Hao. et al. Bioconjugate Chemistry (2018), 29(11), 3833-3840.\u003c\/li\u003e\n\u003c\/ul\u003e\n    \u003c\/div\u003e\n    \n\n    \u003c!-- Faq --\u003e\n    \n\n    \u003c!-- References --\u003e\n    \n\n\n    \u003cscript\u003e\n        const coaSearchButton = document.getElementById('coa-search-button');\n        coaSearchButton.addEventListener('click', async function() {\n            const coaLinkInput = document.getElementById('coa-link-input');\n            const spinElement = document.querySelector('.search-spin');\n            const notFoundElement = document.querySelector('.coa-not-found');\n\n            const lot = coaLinkInput.value.trim().toUpperCase();\n            if (lot.length \u003e 0) {\n                spinElement.style.display = 'block';\n                notFoundElement.style.display = 'none';\n\n                const url = `https:\/\/web.jkchemical.com\/partial\/coaFileLotNumber\/${lot}`;\n                await fetch(url).then((res) =\u003e {\n                    if (res.status === 200) {\n                        window.open(url, '_blank');\n                    } else {\n                        notFoundElement.style.display = 'block';\n                    }\n                }).finally(() =\u003e {\n                    spinElement.style.display = 'none';\n                });\n            }\n        });\n    \u003c\/script\u003e\n\n\n\u003c\/div\u003e","brand":"J\u0026K Chemical","offers":[{"title":"1×1MG","offer_id":45728273891518,"sku":"JK9146843_1_MG","price":1428.6,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0506\/0005\/0878\/files\/GeneralChemical_optimized_21fc6cf7-e472-4ca6-b176-eeaeb0109127.png?v=1776301022","url":"https:\/\/www.jk-sci.com\/products\/a019146843","provider":"J\u0026K Scientific LLC","version":"1.0","type":"link"}